Institute of Physiology

The scientific focus of the Institute of Physiology, CCM (Director: Professor Dr. Axel R. Pries) is circulation. Investigations of molecular and vascular processes, organ perfusion and human physiology including clinical studies are performed.

The intense cooperation of the different research groups of the Institute with clinical, scientific and industrial partners is clearly reflected by the foundation of the “Center of Space Medicine Berlin” (Zentrum für Weltraummedizin Berlin) in cooperation with sponsors of space industry and federal authorities and of the “Research Alliance ‘Organ Perfusion’” (Forschungsverbund Organperfusion) in cooperation with the undefined"German Heart Center Berlin" (Deutsches Herzzentrum Berlin). Three of the professorships of these research focuses are externally sponsored and of high relevance for the output of the Institute in research and teaching.

In the undefined "Center of Space Medicine Berlin" (Zentrum für Weltraummedizin Berlin), effects of micro-g (or weightlessness, respectively) on the human organism under medical-physiological and psychological aspects are investigated. For example, there is a rapid loss of bone and muscle substance due to the lack of gravity in space. In order to allow people a longer stay in space, it is important to know about amount and velocity of these processes. Most recent methods are applied to clarify these cellular and molecular reconstructive mechanisms.

In the field of circulatory research, several research groups and guest scientists at the Institute investigate problems of great scientific and medical importance: vascular and cellular mechanisms of blood flow regulation, especially in microcirculation, pulmonary hypertension, vessel generation and degeneration (angiogenesis/angioadaptation), organ perfusion and perfusion disorders (ischemia/reperfusion), leukocyte function and inflammation. Another important research area is molecular atherosclerosis where initial molecular changes leading to atherosclerotic damages of the vessel wall are analyzed.

Besides research, teaching is one of the main tasks of the institute: students of the Charité do their basic studies here during their first four semesters.

 

 

Research Association Organperfusion

Director: Prof. Dr. AR Pries, Prof. Dr. W. Kübler, Prof. Dr. H. Habazettl
Cooperation: Prof. Dr.
H. Kuppe - DHZB

The research collaboration Organperfusion deals with the experimental study of clinical problems in vascular regulation and organ perfusion and the development of appropriate therapeutic approaches. The research topics covered include microcirculation and clinical microcirculation, endothelial function, angiogenesis and Angioadaptation, rheology, Lungenendstrombahn and tumor microcirculation

News: Interview Circulation (November 16, 2010)

Center of Space Medicine

In the undefinedCenter of Space Medicine, effects of micro-g (or weightlessness, respectively) on the human organism under medical-physiological and psychological aspects are investigated.

 

Detailed information can be found here.

 

Besides research, teaching is one of the main tasks of the institute: students of the Charité do their basic studies here during their first four semesters.

Picture: Novespace